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pentobarbital will lower the extent or impact of efavirenz by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.pentobarbital will reduce the extent or influence of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. The efficacy of hormonal contracep